Joint Health Raw Material-non-denatured Type II Collagen
Aug 11, 2021
For sportsman, whether they are professional athletes or amateurs, joint health can be crucial.
When it comes to bone and joint health, apart from glucosamine and chondroitin sulfate, there is a family of ingredients that not only take care of the hydration of the skin, but also benefit the health of the joints, and it is - collagen.
Collagen is a structural protein of the extracellular matrix, containing one or several regions of triple helix structure consisting of alpha-chains. More than 20 different types of collagen have been identified.
Briefly, collagen type I and III are mainly found in connective tissues such as skin vessels, while collagen type II (CII) is mainly produced by cartilage cells and has a dense fibrous structure, mostly found in bones, joints, tendons and other tissues. It is the main organic component of the cartilage matrix and is the characteristic protein of cartilage tissues, which can bind tightly with polysaccharides and make cartilage flexible to absorb shocks and bear loads.
Type II collagen can be subdivided into denatured type II collagen and non-denatured type II collagen (Undenatured type II collagen) according to whether it maintains an intact triple helix structure, of which
Denatured type II collagen: with varying degrees of disruption of the triple helix structure, its biocompatibility and immunoreactivity are greatly reduced. If the triple helix structure is severely disrupted, or even if the peptide bond is broken, type II collagen loses its binding properties to other molecules such as polysaccharides and loses its biological activity, and is absorbed and used by the body like a normal protein.
Non-denatured type II collagen: It maintains the intact triple helix structure, has good biocompatibility and low antigenicity, and can prevent or relieve osteoarthritis and rheumatoid arthritis by inducing immune tolerance with suitable concentration of non-denatured type II collagen.
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