Fish collagen is a
promising new biomedical material that offers several advantages over collagen
derived from terrestrial mammals. One of its primary benefits is its good
biological safety. Fish collagen is similar in structure and function to
mammalian collagen, but has lower immunogenicity and better safety. This means
it poses a lower risk of zoonotic virus transmission and is safer for clinical
use. In vivo and in vitro biocompatibility studies have shown that fish
collagen gel extract is sterile and non-toxic, with no evidence of
sensitization, chromosomal aberration, intradermal reaction, acute systemic
toxicity, pyrogen reaction, or hemolytic reaction.
Another advantage of fish
collagen is that it can circumvent religious barriers in certain regions and
groups. Due to religious beliefs, pig-derived collagen medical products cannot
be used clinically in Islamic countries and regions. Fish collagen, on the
other hand, does not have these religious restrictions and can benefit patient
groups in related regions and countries more smoothly.
Fish collagen also has the
advantage of being abundant in source. China is a major producer of aquatic
products and generates a large amount of fish processing by-products every
year. Approximately 40% of these by-products are fish skins, which are often
considered waste and discarded. This not only ignores their potential value but
can also cause environmental pollution. The application and development of fish
collagen in the medical field provides a more economical and safer source of
new collagen materials while also increasing the added value of fish skin, a
by-product of aquatic product processing. This reduces pressure on
environmental protection and aligns with the national goal of building a marine
power strategic orientation.
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